Prof. Michael Koutsilieris | Experimental methods | Best Academic Researcher Award

Prof. Michael Koutsilieris, MD, PhD, is an internationally recognized endocrinologist, physiologist, and academic leader whose research has made seminal contributions to molecular endocrinology, endocrine oncology, and translational medicine. His scientific career bridges fundamental molecular physiology with clinical application, particularly in hormone-dependent diseases, bone metabolism, and cancer progression. With formal training at the National and Kapodistrian University of Athens and McGill University, Prof. Koutsilieris developed an early and sustained focus on the molecular mechanisms underlying prostate cancer metastasis, especially osteoblastic bone involvement, a theme that has remained central to his research trajectory. A defining contribution of his work is the elucidation of endocrine and paracrine signaling pathways that regulate bone remodeling and tumor–bone interactions in prostate cancer. His pioneering studies on prostate-derived mitogenic factors and their selective activity on osteoblasts provided foundational insights into the pathophysiology of skeletal metastases. These discoveries have influenced both experimental research and clinical strategies aimed at targeting metastatic disease. Beyond oncology, his research has expanded to include molecular mechanisms of endometriosis, reproductive endocrinology, metabolic disorders, and the systemic effects of exercise as medicine, emphasizing prevention, functional health, and quality of life. Prof. Koutsilieris has published extensively, with more than 375 peer-reviewed publications indexed in PubMed, over 17,700 citations, and an h-index of 71, reflecting sustained international impact. His work integrates molecular biology, physiology, and clinical endocrinology, advancing understanding of hormone signaling, cellular microenvironments, and disease progression. In parallel, he has been deeply engaged in medical education, curriculum development, and the promotion of physiology as a core discipline in modern medical training.

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